The exception to the rule is the DOT1 family, members of which methylate K79 within the globular region of histone H3 and that are structurally not related to SET-area proteins four - 6 Latest work means that SET-domain-containing proteins methylate a few [proteins](https://ipmanage.sumedangkab.go.id/koreymeagher9/solicitor-law-firms8146/wiki/%27Largest-Loser%27-Star-Dolvett-Quince-Debates-Best-Diets-With-Bethenny-Frankel) in addition to histones (see later)
