Some consultants imagine that the adverse results of yo-yo dieting go beyond the bodily and emotional tolls of being obese or obese. The exception to the rule is the DOT1 household, members of which methylate K79 within the globular region of histone H3 and that are structurally not associated to SET-area proteins four - 6 Recent work suggests that SET-domain-containing proteins methylate a couple of proteins in addition to histones (see later)
