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In contrast with mouse thymocytes, mouse ES cells comprise larger levels of whole genomic H3K4me3 and have larger H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 forty six In agreement with this, global decreases in H3K4me3 levels happen throughout retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic modifications in H3K4me3 profiles at particular units of genes throughout ES cell differentiation. |
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